3D models of neuron to help Parkinson’s patients

London, June 26 (IANS) In a major step towards development of personalised drugs for Parkison’s patients, researchers have managed to grow three dimensional models of cells that are lost with the progress of the disease.

The progressive loss of neurons in the brain of Parkinson’s patients is slow yet inexorable. So far, there are no drugs that can halt this insidious process.

“This is an important step towards personalised drug development,” said study leader Ronan Fleming from Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg.

Parkinson’s disease is characterised in particular by death of dopamine-producing neurons in the Substantia nigra of the midbrain.

It is already possible to grow these dopaminergic neurons in cell cultures.

“But most such cell cultures are two-dimensional, with the cells growing along the base of a petri dish, for example,” Fleming said.

“Instead, we have the neurons grow in a gel that yields a far better model of their natural, three-dimensional environment.”

The scientists are confident this system could greatly facilitate the continuing search for therapeutic agents in future as it models the natural conditions in the brain more realistically than other systems available so far.

It is also significantly cheaper to employ in the laboratory, the researchers said.

As a next step, Fleming’s team and their international collaborators want to study cells from patients and to test potential active pharmaceutical ingredients.

Promising substances will then be tested in mice, the researchers said.

The results were recently published in the journal Lab on a Chip.

Leave a Reply

Please enter your comment!

The opinions, views, and thoughts expressed by the readers and those providing comments are theirs alone and do not reflect the opinions of www.mangalorean.com or any employee thereof. www.mangalorean.com is not responsible for the accuracy of any of the information supplied by the readers. Responsibility for the content of comments belongs to the commenter alone.  

We request the readers to refrain from posting defamatory, inflammatory comments and not indulge in personal attacks. However, it is obligatory on the part of www.mangalorean.com to provide the IP address and other details of senders of such comments to the concerned authorities upon their request.

Hence we request all our readers to help us to delete comments that do not follow these guidelines by informing us at  info@mangalorean.com. Lets work together to keep the comments clean and worthful, thereby make a difference in the community.

Please enter your name here