Bangalore: Six Miscarriages and 19 Long Years Later, Lakshmi Gets 2 Bonny Babies!


Bangalore: Gunasheela Hospital based in the city has proudly announced the birth of a baby girl by a woman who was conceived through the husband?s White Blood Cells after 6 Recurrent Pregnancy Losses.

This method of treatment was first introduced by Dr Sulochana Gunasheela. Several babies have been born through this treatment at this hospital. 


This treatment is called Allogenic Lymphocyte Therapy (Paternal Leucocyte Injection).

The foetus is considered foreign to the mother as the foetus contains maternal and paternal components.

The paternal component is foreign to the mother. In a normal pregnancy, the paternal human leucocyte antigen (HLA) is identified by the mother?s immune system as a result of which several antibodies are produced. These antibodies form a coating around the embryo and prevent the mother from recognizing it as foreign. 

There have been many trials which have showed a success rate of almost 67% with this therapy compared to 36% in the control groups.

Some of these antibodies include anti-paternal cytotoxic antibodies (APCA) , anti-idiotypic antibodies (Ab2), & mixed lymphocyte reaction blocking antibodies (MLR-Bf).

These antibodies form a coating around the embryo and prevent the mother from recognizing it as foreign.

There have been many trials which have showed a success rate of almost 67% with this therapy compared to 36% in the control groups.

The doctors at the Gunasheela Hospital have used the same for Lakshmi Bai snf have managed to help her to complete her family with one son and now a daughter.

Lakshmi Bai’s case

Probably no aspect of infertility is more traumatic than becoming pregnant and then losing the baby to miscarriage. And while most women who miscarry do go on to give birth to a healthy baby in the next pregnancy, infertility specialists are often called in to find out the cause for the Recurrent Pregnancy Loss and recommend treatment.

For the Lakshmi Bai and Eshwar Singh couple, the story was no different.  In fact it had been extremely traumatic as they had suffered 6 consecutive miscarriages in their 19 years of married life.  They visited Gunasheela Surgical and Maternity Hospital here with a desperate hope of carrying home a live baby after all their previous arduous journey towards experiencing parenthood. 

After 6 miscarriages, this couple went home happily carrying a live and healthy male baby on December 31, 2011 from Gunasheela Surgical and Maternity Hospital under the able supervision and monitoring of the late Dr Sulochana Gunasheela, who had evaluated the couple for cause of Recurrent Pregnancy Loss in her hospital.

Since none of the tests revealed any obvious cause of Recurrent Pregnancy Loss, Dr Sulochana and Dr Devika Gunasheela decided to transfuse leucocyte fraction of paternal blood (husband?s blood) to Lakshmi Bai, both pre-conceptional and post-conceptional, in order to combat immunological cause of rejection of embryo by the mother.

The journey of 9 months of pregnancy was also very challenging both for Dr Sulochana and Dr Devika, and the couple, since it required repeated admissions in the hospital for constant, close monitoring.  The patient was admitted from the 25th week of pregnancy until she walked home with her bundle of joy.

The patient?s trust and faith in the treatment offered to her in her 7th pregnancy gave her enough strength to opt for the next pregnancy.  This time she was managed under the able supervision of Dr Devika at Gunasheela Surgical and Maternity Hospital with immunological therapy in the form of paternal leucocyte transfusion and close monitoring throughout pregnancy.  Lakshmi Bai delivered a beautiful princess on August 9, 2013 in the same hospital.

Incidence of pregnancy loss among all women is about 20%.  After two miscarriages, however, the risk rises to 25% – 30%.  For a woman who had three consecutive miscarriages but no history of live births, the next pregnancy has a 30-45% chance of ending in miscarriage.

Cause for miscarriage can be identified in only 50% of cases.  By and large, the causes could be genetic, uterine anomalies, cervical incompetence, leutal phase defects, infections or immunological causes.

Tips to women on preventing Recurrent Pregnancy Loss:

? Keep in mind that even if the cause for your miscarriages is unknown, you have about 60-70% chance of having a successful outcome with your next pregnancy.
? If the cause for your miscarriage is known, specific treatment can improve your chances for a successful pregnancy.
? Maintain healthy weight and exercise regularly; avoid caffeine, alcohol and smoking. Consider folic acid supplementation and baby aspirin therapy. Seek support from professionals or family members to help you cope with the emotional difficulties often experienced after a miscarriage.
? Some patients consider gestational surrogacy (patient?s embryos generated from IVF treatment-implanted into another woman?s womb) in cases of unexplained high order recurrent pregnancy loss.
? If you are over 40 with recurrent pregnancy loss, the problem may be attributed to poor egg quality.  In such cases, Donor egg IVF can be considered.

from special correspondent
with inputs from media release

Author: Special correspondent