Genes behind lung disease in smokers decoded

London, Sep 28 (IANS) British researchers have discovered six independent genetic variants associated with lung health and chronic obstructive pulmonary disease (COPD) — revealing association with lung disease and smoking behaviour.

They also found genetic variants associated with COPD in people who have never smoked.

“Understanding the genetic basis of airflow obstruction and smoking behaviour is key to determining the mechanisms which cause COPD,” said professor Ian Hall from Queen’s Medical Centre at University of Nottingham.

Hall, along with professor Martin Tobin from University of Leicester and colleagues sampled individuals from the “UK Biobank” with the best, average or the poorest lung function among heavy smokers and never smokers.

Using a new genotyping array, which measures over 800,000 genetic variants in each participant, the researchers were able to compare lung health and smoking behaviour with both common and rare genetic variations across the whole human genome.

One of these signals is the first example of structural variation of the human genome affecting lung health.

The team found that the numbers of copies of duplicated sequence of the genome on Chromosome 17 was associated with lung health in heavy smokers and also in never smokers.

This, and other findings in the study, point to possible widespread effects on gene regulation and, in turn, protein production.

Chronic obstructive pulmonary disease (COPD) is a global public health concern and is currently the third leading cause of death worldwide.

For the prevention of COPD and other smoking-related diseases, five independent genetic variants were also discovered which were associated with heavy smoking.

“These findings, taken together with previous findings, will help define pathways underlying predisposition to development of COPD and smoking behaviours,” the authors noted.

This will potentially give rise to novel therapeutic strategies for the management of airway disease and prevention of nicotine addiction.

The research was published in the journal The Lancet Respiratory Medicine.

Leave a Reply

Please enter your comment!

The opinions, views, and thoughts expressed by the readers and those providing comments are theirs alone and do not reflect the opinions of www.mangalorean.com or any employee thereof. www.mangalorean.com is not responsible for the accuracy of any of the information supplied by the readers. Responsibility for the content of comments belongs to the commenter alone.  

We request the readers to refrain from posting defamatory, inflammatory comments and not indulge in personal attacks. However, it is obligatory on the part of www.mangalorean.com to provide the IP address and other details of senders of such comments to the concerned authorities upon their request.

Hence we request all our readers to help us to delete comments that do not follow these guidelines by informing us at  info@mangalorean.com. Lets work together to keep the comments clean and worthful, thereby make a difference in the community.

Please enter your name here