Lack of stem cells leads to repeat miscarriages: Study

London, March 8 (IANS) In a development that could lead to new treatment for those who have suffered failed pregnancies, researchers have discovered that a lack of stem cells in the womb lining causes thousands of women to suffer from recurrent miscarriages.

“We have discovered that the lining of the womb in the recurrent miscarriage patients we studied is already defective before pregnancy,” said lead researcher Jan Brosens, professor at University of Warwick in England.

“I can envisage that we will be able to correct these defects before the patient tries to achieve another pregnancy. In fact, this may be the only way to really prevent miscarriages in these cases,” Brosens noted.

The findings were published in the journal Stem Cells.

Between 15-25 percent of pregnancies end in miscarriage and one in 100 women trying to conceive suffer recurrent miscarriages, defined as the loss of three or more consecutive pregnancies, the study pointed out.

The researchers examined tissue samples from the womb lining, donated by 183 women.

The team found that an epigenetic signature — which is typical of stem cells — was absent in cultures established from womb biopsies taken from women suffering recurrent miscarriages.

Indeed, fewer stem cells could be isolated from the lining of the womb from recurrent miscarriage patients when compared to women in the study’s control group.

The researchers further found that a stem cell shortage accelerates cellular ageing in the womb.

“Cultured cells from women who had had three or more consecutive miscarriages showed that ageing cells in the lining of the womb don’t have the ability to prepare adequately for pregnancy,” Brosens explained.

Leave a Reply

Please enter your comment!

The opinions, views, and thoughts expressed by the readers and those providing comments are theirs alone and do not reflect the opinions of www.mangalorean.com or any employee thereof. www.mangalorean.com is not responsible for the accuracy of any of the information supplied by the readers. Responsibility for the content of comments belongs to the commenter alone.  

We request the readers to refrain from posting defamatory, inflammatory comments and not indulge in personal attacks. However, it is obligatory on the part of www.mangalorean.com to provide the IP address and other details of senders of such comments to the concerned authorities upon their request.

Hence we request all our readers to help us to delete comments that do not follow these guidelines by informing us at  info@mangalorean.com. Lets work together to keep the comments clean and worthful, thereby make a difference in the community.

Please enter your name here