New molecule to fight obesity identified

New molecule to fight obesity identified

New York, Oct 16 (IANS) Activating the oestrogen — the primary female sex hormone — receptor-beta protein with a chemical has the potential to increase metabolism as well as help reduce obesity, say researchers including one of Indian-origin.

The findings showed that the activation of a chemical called beta-LGND2 by the oestrogen receptor-beta can help reduce obesity and metabolic diseases in mice by converting bad fat (white fat) into good fat (brown fat).

This is significant as brown fat increases metabolism and may facilitate weight loss, the researchers said.

“Although there is a general misperception that obesity is not a life-threatening condition, obesity is the underlying cause for several diseases that could result in mortality,” said Ramesh Narayanan, a researcher at the University of Tennessee in the US.

“Safe and effective treatment for obesity is highly needed, and targeting oestrogen receptor-beta might be one of the strategies to safely combat obesity,” Narayanan added.

To make their discovery, Narayanan and colleagues used three groups of mice.

One group was fed with normal rodent diet, while two groups were fed with high-fat diet to make them obese. One of the two high-fat diet-fed groups was treated with beta-LGND2.

The beta-LGND2-treated mice were significantly leaner than the other mice fed on high-fat diet and they also had higher body temperature and oxygen consumption, indicating higher metabolism rate.

The research was published online in The FASEB Journal.

Leave a Reply

Please enter your comment!

The opinions, views, and thoughts expressed by the readers and those providing comments are theirs alone and do not reflect the opinions of www.mangalorean.com or any employee thereof. www.mangalorean.com is not responsible for the accuracy of any of the information supplied by the readers. Responsibility for the content of comments belongs to the commenter alone.  

We request the readers to refrain from posting defamatory, inflammatory comments and not indulge in personal attacks. However, it is obligatory on the part of www.mangalorean.com to provide the IP address and other details of senders of such comments to the concerned authorities upon their request.

Hence we request all our readers to help us to delete comments that do not follow these guidelines by informing us at  info@mangalorean.com. Lets work together to keep the comments clean and worthful, thereby make a difference in the community.

Please enter your name here