Why ‘offline’ rehearsal can make memory permanent

Toronto, Aug 5 (IANS) Rehearsing in the brain after learning something new can help solidify memory by stimulating electrical activity in the brain, says a new study.

“Learning is thought to occur ‘online’ by creating new or strengthened synaptic connections,” one of the authors of the study Clayton Dickson, psychology professor at the University of Alberta in Edmonton, Canada.

“However, we also know that the period directly following learning–when the brain is ‘offline’–is critical for solidifying that information,” Dickson noted.

“Offline” activity, or neural replay, is the process by which the brain rehearses what has been learned in order to strengthen the most important memories.

The permanence of memories has long thought to be mediated solely by the production of new proteins.

But according to the new study, he electrical activity of the brain may be a more primary factor in memory solidification.

“It is not just protein synthesis, long the dominant biological model, but also ‘offline’ memory rehearsal in the brain that leads to memory solidification,” Dickson noted.

Although agents that block protein synthesis can block future retrieval of this information at this stage, the findings suggest that that this might be caused by disruption of electrical activity.

“Understanding how our brains solidify memories is essential for treating memory disorders and, in the case of post-traumatic stress disorder, for potentially ridding oneself of bothersome memories,” Dickson said.

“The more we understand about the process, the more likely we can find a way for people to improve their good memories and eliminate the bad,” he pointed out.

The findings appeared in the Journal of Neuroscience.


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