Indian-American scientist engineers T-cells to treat pancreatic cancer

New York, April 19 (IANS) In ground-breaking research, an Indian-American scientist has engineered T-cells — a type of immune cells — to break the pancreatic cancer’s physical and immunological walls using immunotherapy.

Dr Sunil Hingorani, member of the clinical research and public health sciences divisions at Fred Hutchinson Cancer Research Center, and colleagues created T-cells with a high affinity to a relatively tumour-specific antigen.

Dr Hingorani looked for proteins — also found in the linings of the heart and lungs — that are expressed in unusually large amounts in the tumour cells and minimally expressed elsewhere.

The T-cells then were engineered to attack those. In the tests conducted on mice with pancreatic tumours, the engineered T-cells killed those cells over a 10-day period.

Additionally, Hingorani and his team have worked to develop an enzyme that can help defeat the tumour’s high interstitial pressures and potentially open the door for greater penetration and effectiveness of T cells and other types of agents.

By the end of the year, Dr Hingorani hopes to have the human version of the T-cell in clinical trials.

The findings were recently presented at the American Association for Cancer Research Annual Meeting 2016 in New Orleans, US.

Leave a Reply

Please enter your comment!

The opinions, views, and thoughts expressed by the readers and those providing comments are theirs alone and do not reflect the opinions of www.mangalorean.com or any employee thereof. www.mangalorean.com is not responsible for the accuracy of any of the information supplied by the readers. Responsibility for the content of comments belongs to the commenter alone.  

We request the readers to refrain from posting defamatory, inflammatory comments and not indulge in personal attacks. However, it is obligatory on the part of www.mangalorean.com to provide the IP address and other details of senders of such comments to the concerned authorities upon their request.

Hence we request all our readers to help us to delete comments that do not follow these guidelines by informing us at  info@mangalorean.com. Lets work together to keep the comments clean and worthful, thereby make a difference in the community.

Please enter your name here