Long-term use of antibiotics

Long-term use of antibiotics could disrupt brain function

London, May 20 (IANS) Treatments involving long-term use of antibiotics have the potential to disrupt brain functions, suggests a new research which found that healthy gut bacteria is crucial to keeping the mind sharp.

A special kind of immune cell serves as an intermediary between gut bacteria and the brain, showed the findings that could also help to alleviate the symptoms of mental disorders.

The gut and the brain “talk” to one another via hormones, metabolic products or direct neural connections.

In this study, the researchers switched off the gut microbiome in mice, that is their intestinal bacteria, with a strong concoction of antibiotics.

Compared to the mice that had not undergone treatment, they subsequently observed significantly fewer newly formed nerve cells in the hippocampus region of the brain.

The memory of the treated mice also deteriorated because the formation of these new brain cells – a process known as neurogenesis – is important for certain memory functions.

As well as impaired neurogenesis, the researchers also found that the population of a specific immune cell in the brain – the Ly6C(hi) monocytes – decreased significantly when the microbiota was switched off.

Applied to humans, the findings do not show that all antibiotics disrupt brain function, as the combination of drugs used in the study was extremely potent.

“It is possible, however, that similar effects could result from treatments involving long-term use of antibiotics,” said one of the researchers Susanne Wolf from Max Delbruck Centre for Molecular Medicine in the Helmholtz Association, Berlin, Germany.

The findings were published in the journal Cell Reports.

The research team also found that the antibiotics may affect neurogenesis directly, and not act only via the gut bacteria.

The new study is also of significance for treating people with mental disorders such as schizophrenia or depression, who also have impaired neurogenesis, Wolf said.

“In addition to medication and physical exercise, these patients could potentially also benefit from probiotic preparations,” Wolf noted.

Leave a Reply

Please enter your comment!

The opinions, views, and thoughts expressed by the readers and those providing comments are theirs alone and do not reflect the opinions of www.mangalorean.com or any employee thereof. www.mangalorean.com is not responsible for the accuracy of any of the information supplied by the readers. Responsibility for the content of comments belongs to the commenter alone.  

We request the readers to refrain from posting defamatory, inflammatory comments and not indulge in personal attacks. However, it is obligatory on the part of www.mangalorean.com to provide the IP address and other details of senders of such comments to the concerned authorities upon their request.

Hence we request all our readers to help us to delete comments that do not follow these guidelines by informing us at  info@mangalorean.com. Lets work together to keep the comments clean and worthful, thereby make a difference in the community.

Please enter your name here