New compound heals diabetic wound faster

New York, Nov 24 (IANS) Researchers have discovered a compound that accelerates diabetic wound healing, which may open the door to new treatment strategies.

Non-healing chronic wounds are a major complication of diabetes, but the reasons why diabetic wounds are resistant to healing are not fully understood, and there are limited therapeutic agents that could accelerate or facilitate their repair.

A team of researchers from University of Notre Dame in Indiana, US previously identified two enzymes called matrix metalloproteinases (MMPs), MMP-8 and MMP-9, in the wounds of diabetic mice.

The researchers used the MMP-9 inhibitor referred to as ND-322, which accelerated wound healing in diabetic mice.

In this new study, the researchers report the discovery of a better MMP-9 inhibitor referred to as ND-336.

“ND-336 is a six-fold more potent inhibitor than ND-322 and has 50-fold selectivity towards inhibition of MMP-9 than MMP-8,” said lead researcher Mayland Chang.

“The compound ND-336 has potential as a therapeutic to accelerate or facilitate wound healing in diabetic patients,” Chang pointed out.

The researchers said they are currently recruiting diabetic patients to ascertain the levels of MMP-8 and MMP-9 in their wounds.

The study appeared in the journal Proceedings of the National Academy of Sciences (PNAS).

Leave a Reply

Please enter your comment!

The opinions, views, and thoughts expressed by the readers and those providing comments are theirs alone and do not reflect the opinions of www.mangalorean.com or any employee thereof. www.mangalorean.com is not responsible for the accuracy of any of the information supplied by the readers. Responsibility for the content of comments belongs to the commenter alone.  

We request the readers to refrain from posting defamatory, inflammatory comments and not indulge in personal attacks. However, it is obligatory on the part of www.mangalorean.com to provide the IP address and other details of senders of such comments to the concerned authorities upon their request.

Hence we request all our readers to help us to delete comments that do not follow these guidelines by informing us at  info@mangalorean.com. Lets work together to keep the comments clean and worthful, thereby make a difference in the community.

Please enter your name here